He died (aged about 56) of dysentery, a common disease in the tropics at the time, while anchored off the coast of Portobelo, Panama.
Before dying, he asked to be dressed in his full armor. He was buried at sea in a sealed lead-lined coffin, near Portobelo, a few miles off the coastline. It is supposed that his final resting place is near the wrecks of two British ships, the Elizabeth and the Delight, scuttled in Portobelo Bay. Divers continue to search for the coffin.. Drake’s body has never been recovered.
Read the complete article on History.com.
Dean Calin of Bounding Main wrote a song about Drake’s voyage that circumnavigated the globe. You can listen to Call of the Sea here: https://boundingmain.bandcamp.com/track/call-of-the-sea